Buffer demand scales with titre, and so do the tanks, Water for Injection (WFI) and floor space needed to prepare it. Inline dilution lets a facility store buffer as concentrate and make process-ready buffer on demand.

We have just delivered three In-Line Dilution (ILD) skids for a biologics DS facility expansion in Western Europe. These skids blend concentrate with WFI and are designed to maintain the dilution ratio across the full range of flow rates required by the process, including when demand changes mid-step.

How Flow Technology’s ILD skids do that:
➡️ Quattroflow pumps paired with Coriolis flowmeters and back-pressure control valves specified for stable low-pulsation flow, for accurate, stable dilution across a wide pump range. A wider range per pump means fewer pumps on the skid compared to a conventional design, reducing skid footprint and cost.
➡️ Conductivity and pH measurement downstream of the mixer, so the buffer is monitored before it reaches the process.
➡️ AL6XN pumps, instruments and pipework on the concentrate lines, providing corrosion resistance when handling high-salt concentrates.
➡️ Sloped pipework designed to drain fully, within a compact footprint.

This is one part of a wider programme between the Flow Technology team, the EPC contractor and the customer. Four chromatography skids with integrated on-skid inline dilution are about to go through FAT in our workshop.