Flow Technology delivered a novel chromatography solution for a biotech customer introducing a chilled process step. A purpose-built cold room was not feasible due to cost and space requirements, so we engineered an alternative approach. The system was designed around a 2000L prefabricated refrigerator, with a fully mobile chromatography skid that could be wheeled in and out of the chilled zone. Heat-generating components, such as pumps and control panels, were located outside of the refrigerated area to ensure stability and efficiency.

The system incorporated a Quattroflow pump (50–450 l/hr), Sartorius process cartridge filter housings with UniBloc-pump bubbletrap, GEMÜ diaphragm valves, SVF ball valves, and comprehensive inline monitoring for conductivity, pH, UV, air, flow, level, pressure, and temperature. Control was achieved through RIO and MCP panels, and the entire system was fully tested at Flow Technology’s workshop before delivery.

This bespoke refrigerated chromatography system reduced capital and maintenance costs while minimising footprint, providing the customer with a robust and cost-optimised solution for chilled bioprocessing applications.